Lake Santa Fe Vacation Rental. Comfortable 3 bedroom Home with additional 1 bedroom Cabin Efficiency. The house has a very open living area with 3 bedrooms (all queen size), 1 inside full bath, and 1 bath with shower in the garage. The efficiency cabin adds another queen size bed and has a small kitchen and bath with shower. The cabin opens up to a dock/deck over the water. The lakefront is great for swimming and relaxing with nice sandy beach, long dock, large oak, awesome view and privacy. Lake Santa Fe is 6000-acres of natural beauty, 9 miles long by 3 miles wide. The State of Florida has designated this as an outstanding waterway, ideal for fishing, swimming, and skiing. Close to University of Florida, Gainesville, in between the cities Melrose and Keystone Heights.